GLP-1 agonists are a class of medications originally developed to treat type 2 diabetes. However, they’ve also become a hot topic in the weight loss world due to their impressive results. But what exactly are they, and how do they work?

What are GLP-1 Agonists?

GLP-1 stands for glucagon-like peptide-1. It’s a naturally occurring hormone in your gut that plays a role in regulating blood sugar and appetite. GLP-1 agonists are medications that mimic the action of this hormone.

How Do They Work for Weight Loss?

GLP-1 agonists work in several ways to promote weight loss:

• Slows gastric emptying: This means food stays in your stomach longer, making you feel fuller for longer.
• Increases insulin release: This helps regulate blood sugar and reduces cravings.
• Reduces glucagon secretion: This further aids in blood sugar control.
• May increase feelings of fullness: Some studies suggest GLP-1 agonists may affect brain areas involved in appetite regulation.

Examples of GLP-1 Agonists

• Semaglutide (Ozempic, Wegovy)
• Liraglutide (Victoza, Saxenda)
• Dulaglutide (Trulicity)
• Tirzepatide (Zepbound, Mounjaro)

Important Note: GLP-1 agonists are prescription medications and should only be used under the guidance of a healthcare professional.

The Role of Nutrition

While GLP-1 agonists can be a powerful tool for weight loss, they work best when combined with a healthy diet. Here are some key nutritional considerations:

• Focus on whole foods: The primary emphasis on protein including lean meats and eggs.  From there fill your plate with non-starchy vegetables.  Carbohydrate sources should primarily come from whole food options like potatoes, fruits (primarily berries & low sugar fruits)
• Limit processed foods: These tend to be high in calories, unhealthy fats, and added sugars.
• Stay hydrated: Drink plenty of water throughout the day.
• Portion control: Be mindful of your portion sizes to avoid overeating. Always prioritize finishing protein over the rest of your plate

Potential Benefits Beyond Weight Loss

GLP-1 agonists may offer additional health benefits beyond weight loss, including:

• Improved blood sugar control
• Reduced risk of cardiovascular events
• Reduced inflammation

Potential Side Effects

GLP-1 agonists can cause side effects, including nausea, vomiting, diarrhea, and constipation. These side effects are usually mild and temporary, but it’s important to discuss them with your doctor.

The Bottom Line

GLP-1 agonists can be a valuable tool for weight loss, especially when combined with a healthy diet and lifestyle. It’s important to work with your healthcare provider to determine if they are right for you and to develop a comprehensive weight loss plan.